Therapeutic targeting of Janus kinases
نویسندگان
چکیده
منابع مشابه
Regulation of Janus kinases by SOCS proteins.
JAKs (Janus kinases) are essential mediators of almost all biological signalling events initiated by haemopoietic and immune cytokines. However, aberrant and/or prolonged JAK-induced signalling is detrimental and can give rise to a number of inflammatory and proliferative pathologies. For this reason, the tyrosine kinase activity of the JAKs is carefully regulated at a number of different level...
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BACKGROUND/AIMS Major depressive disorder is a severe, common and often chronic disease with a significant mortality due to suicide. The pathogenesis of major depression is still unknown. It is assumed that a reduction of neurogenesis in the hippocampus plays an important role in the development of major depressive disorder. However, the mechanisms that control proliferation of neuronal stem ce...
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Among the hematologic malignancies, the genetic lesion in chronic myelogenous leukemia (CML) resulting in Bcr-Abl tyrosine kinase has become a hallmark target for therapeutic intervention. Inhibition of Bcr-Abl tyrosine kinase is a poster child for kinasetargeted therapeutics. Unlike CML, chronic lymphocytic leukemia (CLL) does not have a genetic lesion associated with pathophysiology or biolog...
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Neuroblastoma is uniquely sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us to examine downstream effectors of this pathway and identify mitotic regulator Wee1 as an additional therapeutic target in this disease. Wee1 was overexpressed in both neuroblastoma cell lines and high-risk patient tumors. Genetic or pharmacologic abrogation of Wee1 signaling resu...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2008
ISSN: 0105-2896,1600-065X
DOI: 10.1111/j.1600-065x.2008.00644.x